Recently we discussed New drug Daptomycin...so I m Gonna post few facts regarding it:
MOA: cause Cell wall depolarization--> inhibit DNA, RNA and Protein synthrsis
Organism suscetibility: only gm +ve cocci--> staph-->MRSA too, Strep, ENterococci --also GRE
Used for MRSA, Rt sided endocarditis, soft tissue Infection...
Side effect:
Renal Failure
rhabdomyolysis---> so be careful while using dapto and statin together.
Limitation:
Cant be used in Pneumonia as It binds to surfactant ..
MOA: cause Cell wall depolarization--> inhibit DNA, RNA and Protein synthrsis
Organism suscetibility: only gm +ve cocci--> staph-->MRSA too, Strep, ENterococci --also GRE
Used for MRSA, Rt sided endocarditis, soft tissue Infection...
Side effect:
Renal Failure
rhabdomyolysis---> so be careful while using dapto and statin together.
Limitation:
Cant be used in Pneumonia as It binds to surfactant ..
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