Daptomycin

Recently we discussed New drug Daptomycin...so I m Gonna post few facts regarding it:

MOA: cause Cell wall depolarization--> inhibit DNA, RNA and Protein synthrsis

Organism suscetibility: only gm +ve cocci--> staph-->MRSA too, Strep, ENterococci --also GRE

Used for MRSA, Rt sided endocarditis, soft tissue Infection...

Side effect:
Renal Failure
rhabdomyolysis---> so be careful while using dapto and statin together.

Limitation:
Cant be used in Pneumonia as It binds to surfactant ..